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Epithelial-Mesenchymal Transition (EMT), Cancer Progression and Role of Aromatase

Ankita Tripathi1, Rekha Gahtori1, Nidhi Negi2, Ashutosh Paliwal1, Penny Joshi2 and Santosh Kumar Upadhyay1

1. Department of Biotechnology, Kumaun University, Bhimtal Campus, Bhimtal, Uttarakhand, India

2. Department of Chemistry, D.S.B.Campus, Kumaun University, Nainital, Uttarakhand, India


Abstract: Epithelial-mesenchymal transition (EMT) is a biological process where polarized epithelial cells undergo various biochemical changes and attain mesenchymal cell like properties. Apart from being involved in normal developmental processes, EMT has been involved in physiopathological transitions such as carcinogenesis-enabling processes while playing important role in therapeutic resistance and imparting enhanced invasion and metastasis. Aromatase is a key enzyme involved in the biosynthesis of estrogen. Aromatase catalyze the aromatization of androgens into estrogens. Mutations in this gene (CYP19A1) results in either increased or decreased Aromatase activity. Though the Cancer link of Aromatase has been studied by many researchers in various tissue backgrounds, there are only limited studies till now exploring the role of Aromatase in EMT. The review focuses on understanding EMT, its role in imparting drug resistance to cancers and regulation of tumorigenesis and EMT by Aromatase.

Key words: Cancer, metastasis, drug-resistance, epithelial mesenchymal transition, EMT, aromatase.
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