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Gentiopicroside, a Potent Free Radical Scavenger, Contributing to the Hepatoprotective Activity of Gentiana kurroo Royle

Karishma Joshi1, Naveen Chandra Pant2, Vandana A. Kumar1 and Atul Kumar3

1. Department of Biochemistry, College of Basic Sciences and Humanties, G. B. P. U. A. & T. Pantnagar, U. S. Nagar. 264145. India

2. Department of Agriculture, Dolphin (P.G.) Institute of Biomedical and Natural Sciences, Dehra Dun. 248007, India

3. Department of Plant Physiology, College of Basic Sciences and Humanties, G. B. P. U. A. & T. Pantnagar, U. S. Nagar. 264145, India


Abstract: Gentiana kurroo Royle is one of the critically endangered medicinal herb of western and northeastern Himalayas. This herb is enriched with immense medicinal potential as the roots of this plant contain huge number of phytochemicals like phenolics, flavonoids, iridoids, glycosides etc, which are valued as hepatoprotective, anti-inflammatory, antibacterial, stomachic, blood purifier and sedatives. The enriched polyphenolic content is responsible for the free radical scavenging activity in the liver leads to hepatoprotactive effects. In the current study the antioxidant activity was estimated by DPPH radical scavenging activity in the methnolic root extract of G. kurroo and of pure gentiopicroside. The antioxident activity (DPPH activity) was expressed in terms of IC50 value as well as trolox equivalents/g. The result illustrated that gentiopicroside showed a positive correlation (r = 0.993) with free radical scavenging activity. The DPPH activity in terms of trolox equivalents was found to be 236.25 µg/g dry weight of roots and 397.82 µg/g of pure gentiopicroside. The findings inferred that gentiopicroside have a definite antioxidant activity and it may contribute significantly to the hepatoprotective effect of Gentiana kurroo Royle.

Key words: Gentiopicroside, Gentiana kurroo royle, gentianaceae, antioxidant activity.
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